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A gonadotrofina coriônica humana (hCG), produzida pelo sinciotrofoblasto, estimula a secreçãeste de testosterona pelas cé especialmentelulas do Leydig em o período crítico da diferenciaçãeste sexual masculina, ou mesmo que, a primeira metade da gestação.
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Esses cordões desenvolvem-se para formar túbulos seminíferos, túbulos retos e rede testicular. As células de Leydig podem ser observadas entre os túbulos a partir da oitava semana7-nove.
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